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A large 24-week trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo when combined with diet and exercise

This research compound demonstrates selective NNMT inhibition in cellular metabolism studies, particularly those examining diet-induced obesity and metabolic rate regulation

AOD9604 acts directly on fat metabolism but doesnt meaningfully raise HGH or IGF1 levels (human safety data)

NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue. Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues